A COMPARISON OF INJECTION TECHNIQUES USING BOTULINUM TOXIN INJECTION FOR TREATMENT OF THE SPASMODIC DYSPHONIA

被引:30
作者
LUDLOW, CL [1 ]
BAGLEY, J [1 ]
YIN, SG [1 ]
KODA, J [1 ]
机构
[1] NIDOCD,VOICE & SPEECH SECT,BETHESDA,MD
关键词
SPASMODIC DYSPHONIA; BOTULINUM TOXIN; DYSPHONIA; DYSPHAGIA;
D O I
10.1016/S0892-1997(05)80038-4
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
The benefit duration and side effects following effective treatment of spasmodic dysphonia or voice tremor using botulinum toxin injection were studied following 477 open trial unilateral or bilateral injections provided to 178 patients. A comparison of unilateral and bilateral injections in male and female patients with adductor spasmodic dysphonia demonstrated an increased benefit duration following unilateral injections in women, longer periods of breathiness in men than in women following bilateral or unilateral injections, and a trend for reduced benefit durations following repeated treatments using bilateral injections. Outcomes were similar in the adductor spasmodic dysphonia and vocal tremor groups following thyroarytenoid injection while benefit durations were reduced and side effects lasted longer in patients with abductor spasmodic dysphonia following cricothyroid injections. Long-term benefit > 1 year occurred in 12.3% of patients following injection.
引用
收藏
页码:380 / 386
页数:7
相关论文
共 18 条
  • [1] Ludlow, Treatment of speech and voice disorders with botulinum toxin, JAMA, 264, pp. 2671-2675, (1990)
  • [2] Consensus Statement, Clinical use of botulinum toxin, NIH Consensus Dev Conf Consens Statement, 8, pp. 1-20, (1990)
  • [3] Jankovic, Brin, Drug therapy: therapeutic uses of botulinum toxin, N Engl J Med, 324, pp. 1186-1194, (1991)
  • [4] Ludlow, Naunton, Terada, Anderson, Successful treatment of selected cases of abductor spasmodic dysphonia using botulinum toxin injection, Otolaryngol Head Neck Surg, 104, pp. 849-855, (1991)
  • [5] Miller, Woodson, Jankovic, Botulinum toxin injection of the vocal fold for spasmodic dysphonia, Arch Otolaryngol Head Neck Surg, 113, pp. 603-605, (1987)
  • [6] Ludlow, Naunton, Sedory, Schulz, Hallet, Effects of botulinum toxin injections on speech in adductor spasmodic dysphonia, Neurology, 38, pp. 1220-1225, (1988)
  • [7] Blitzer, Brin, Laryngeal dystonia: A series with botulinum toxin therapy, Ann Otol Rhinol Laryngol, 100, pp. 85-89, (1991)
  • [8] Ford, Bless, Lowery, Indirect laryngoscopic approach for injection of botulinum toxin in spasmodic dysphonia, Otolaryngol Head Neck Surg, 103, pp. 752-758, (1990)
  • [9] Alfieri, Barontini, Brogelli, Et al., Structural changes in extraocular muscle treated with botulinum toxin (BT) in man, Mov Disord, 5, (1990)
  • [10] Dedo, Izdebski, Intermediate results of 306 recurrent laryngeal nerve sections for spastic dysphonia, Laryngoscope, 93, pp. 9-16, (1983)