APOPTOSIS IN THE CERVIX OF PREGNANT RATS IN ASSOCIATION WITH CERVICAL SOFTENING

被引:45
作者
LEPPERT, PC
YU, SY
机构
[1] Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester General Hospital Division, Rochester, NY
关键词
UTERINE CERVIX; APOPTOSIS; CERVICAL RIPENING; PREGNANCY; EXTRACELLULAR MATRIX; REMODELING OF CERVICAL PROTEINS;
D O I
10.1159/000292546
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Cervical ripening in gestation occurs spontaneously in a timely but species-specific fashion as if it were genetically programmed. This study shows that the numbers of dying smooth muscle cells in the cervix increased along with cervical softening in pregnant rats from day 12 of gestation to day 21. The morphological characteristics of the chromatin cleavage in apoptosis are identified. Internucleosomal DNA fragments in the DNA preparations as well as the ladder pattern of double-stranded DNA observed on gel electrophoresis are observed. The deletion and decrease of the cell population in the cervices was demonstrated by a decrease of total DNA in these tissues. The interesting possibility is raised that programmed smooth muscle cell death in the cervix may be involved in the processes of the cervical ripening.
引用
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页码:150 / +
相关论文
共 38 条
  • [1] Baulieu E.E., 1985, ANTIPROGESTIN STEROI, P1
  • [2] Bowen ID, 1990, PROGRAMMED CELL DEAT
  • [3] RIPENING OF CERVIX WITH EXTRA-AMNIOTIC PROSTAGLANDIN-E2 IN VISCOUS GEL BEFORE INDUCTION OF LABOR
    CALDER, AA
    EMBREY, MP
    TAIT, T
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1977, 84 (04): : 264 - 268
  • [4] CHWALISZ K, 1991, RES PER MED, V10, P119
  • [5] CHWALISZ K, 1986, ACTA ENDOCR-COP S, V11, P12
  • [6] COHEN JJ, 1984, J IMMUNOL, V132, P38
  • [7] EFFECT OF PREGNANCY AND LABOR ON HUMAN CERVIX - CHANGES IN COLLAGEN, GLYCOPROTEINS, AND GLYCOSAMINOGLYCANS
    DANFORTH, DN
    VEIS, A
    BREEN, M
    WEINSTEIN, HG
    BUCKINGHAM, JC
    MANALO, P
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1974, 120 (05) : 641 - 651
  • [8] FLUOROMETRIC QUANTIFICATION OF DNA IN CELLS AND TISSUE
    DOWNS, TR
    WILFINGER, WW
    [J]. ANALYTICAL BIOCHEMISTRY, 1983, 131 (02) : 538 - 547
  • [9] FIGUEROA JP, 1985, PHYSL DEV FETUS NEWB, P505
  • [10] CHANGE IN SOLUBILITY OF TYPE-I COLLAGEN IN HUMAN UTERINE CERVIX IN PREGNANCY AT TERM
    ITO, A
    KITAMURA, K
    MORI, Y
    HIRAKAWA, S
    [J]. BIOCHEMICAL MEDICINE, 1979, 21 (03): : 262 - 270