DETECTION OF HERPESVIRUS TYPE-6 BY POLYMERASE CHAIN-REACTION IN BLOOD-DONORS - RANDOM TESTS AND PROSPECTIVE LONGITUDINAL-STUDIES

被引:32
作者
WILBORN, F
SCHMIDT, CA
ZIMMERMANN, R
BRINKMANN, V
NEIPEL, F
SIEGERT, W
机构
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,INNERE MED ABT,D-14050 BERLIN,GERMANY
[2] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,SCHWERPUNKT HAMATOL & ONKOL ABT,W-1000 BERLIN,GERMANY
[3] BUNDESGESUNDHEITSAMT,ROBERT KOCH INST,W-1000 BERLIN,GERMANY
[4] UNIV ERLANGEN NURNBERG,INST KLIN & MOLEK VIROL,ERLANGEN,GERMANY
关键词
HUMAN HERPESVIRUS TYPE 6; BLOOD DONORS; PCR;
D O I
10.1111/j.1365-2141.1994.tb04995.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In order to evaluate the prevalence of HHV-6 in blood donors, we examined 112 persons by polymerase chain reaction (PCR) and ELISA. KHV-6 antibodies could be detected in 107/111 (96.4%) of the donors. The median ELISA antibody level was 0.451 (range 0.056-0.914). 14 individuals (12.5%) were PCR positive in either oral lavage fluid, urine or buffy coat. Six persons (5.4%) were PCR positive in huffy coat samples. The prospective longitudinal analysis of 11 donors for periods between 7 and 13 weeks revealed that 4/6 persons who were initially PCR negative had positive tests in 9/63 weeks studied, Two persons were consistently PCR positive over the whole observation period of 12 and 13 weeks. HHV-6 variants could be determined in 14 persons as variant A in nine and variant B in fine cases. These observations emphasize the high prevalance of HHV-6 and suggest that some blood donors carry detectable concentrations of the virus and therefore may be a source for transmission of HHV-6. The finding of positive PCR in antibody negative individuals suggests that antibody determination may not be sufficient to identify potentially infectious persons.
引用
收藏
页码:187 / 192
页数:6
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