STRUCTURE AND SEQUENCE OF THE GENE ENCODING THE ALPHA-SUBUNIT OF RAT TRANSLATION INITIATION FACTOR-2B

被引：5

作者：

FLOWERS, KM ^{[1
]}

MELLOR, H ^{[1
]}

KIMBALL, SR ^{[1
]}

JEFFERSON, LS ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 02期

关键词：

PROTEIN SYNTHESIS; INITIATION FACTOR; GENE; (RAT);

D O I：

10.1016/0167-4781(95)00160-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic initiation factor-2B (eIF-2B) is a heteropentameric guanine nucleotide exchange factor involved in the recycling of eIF-2 during the translation initiation phase of protein synthesis. The activity of eIF-2B is controlled by diverse mechanisms under a wide range of conditions. As part of our studies into the control of the expression of eIF-2B subunit mRNAs, we have isolated and characterized the rat gene encoding the alpha-subunit of eIF-2B. The gene is comprised of 9 exons which are contained within 8.5 kb of genomic DNA. A comparison of the 5'-flanking region of the gene with that of the previously isolated eIF-2B epsilon gene reveals that both possess a potential binding site for the alpha-Pal transcription factor as well as several other regions of homology.

引用

页码：163 / 167

页数：5

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