FR901451, A NOVEL INHIBITOR OF HUMAN-LEUKOCYTE ELASTASE FROM FLEXIBACTER SP .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：12

作者：

FUJITA, T

HATANAKA, H

HAYASHI, K

SHIGEMATSU, N

TAKASE, S

OKAMOTO, M

OKUHARA, M

SHIMATANI, K

SATOH, A

机构：

[1] FUJISAWA PHARMACEUT CO LTD, EXPLORATORY RES LABS, TSUKUBA, IBARAKI 30026, JAPAN

[2] ANALYT RES LABS, YODOGAWA KU, OSAKA 532, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 12期

关键词：

D O I：

10.7164/antibiotics.47.1359

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel human leukocyte elastase (HLE) inhibitor, FR901451 was discovered in the fermentation broth of a bacteria. The bacteria was identified as Flexibacter sp. No. 758. FR901451 has a molecular weight of 1269 and a molecular formula of C60H79N13O19. The mode of inhibition against HLE is competitive, with a Ki value of 9.8 x 10(-9) M.

引用

收藏

页码：1359 / 1364

页数：6

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