INTERACTION OF CEPHALORIDINE WITH MODEL MEMBRANE SYSTEMS AND RAT-KIDNEY LYSOSOMES

被引：5

作者：

FRY, M ^{[1
]}

PLUMMER, DT ^{[1
]}

机构：

[1] UNIV LONDON CHELSEA COLL SCI & TECHNOL,DEPT BIOCHEM,LONDON SW3 6LX,ENGLAND

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90073-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antibiotic cephaloridine has been shown to interact with phospholipid structures, using the techniques of ultraviolet difference spectxoscopy, surface pressure measurements and liposome models. The results indicate that this interaction is at least partly hydrophobic in nature and help explain the disruptive effects of high concentrations of cephaloridine on both artificial and natural phospholipid structures (lysosomes). Low concentrations of cephaloridine were shown to inhibit a lysosomal membrane-bound phospholipase 2 and it is suggested that such an inhibition may explain the cephaloridine-induced stabilization of rat-kidney lysosomes. © 1979.

引用

页码：113 / 124

页数：12

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