DOES MYCOBACTERIUM-TUBERCULOSIS HAVE PLASMIDS

被引：26

作者：

ZAINUDDIN, ZF ^{[1
]}

DALE, JW ^{[1
]}

机构：

[1] UNIV SURREY,DEPT MICROBIOL,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

TUBERCLE | 1990年 / 71卷 / 01期

关键词：

D O I：

10.1016/0041-3879(90)90060-L

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Evidence of the presence of plasmids in Mycobacterium tuberculosis is lacking, whereas they are widespread in some other mycobacterial species. We examined, by agarose gel electrophoresis, a total of 197 clinical isolates of M. tuberculosis, mostly resistant to one or more antibiotics, and were able to detect bands of apparently extrachromosomal DNA at a low level in some isolates. These presumptive plasmids could not be isolated by CsCl/ethidium bromide gradient ultracentrifugation, and may consist of unusual forms of DNA. The possible existence of single stranded plasmid DNA is discussed. © 1990.

引用

页码：43 / 49

页数：7

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