1ST SYNTHESIS OF (+)-SEPTORINE

被引：9

作者：

OHTA, A

KOJIMA, A

SAITO, T

KOBAYASHI, K

SAITO, H

WAKABAYASHI, K

HONMA, S

SAKUMA, C

AOYAGI, Y

机构：

[1] Tokyo College of Pharmacy, Hachioji, Tokyo, 192-03

来源：

HETEROCYCLES | 1991年 / 32卷 / 05期

关键词：

D O I：

10.3987/COM-91-5682

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-Septorine, a metabolite of Septoria nodorum, was synthesized via alanyl-isoleucyl anhydride (2) from L-isoleucine at the first time. Compound (2) was led to a pyrazine-carboxaldehyde (13), which was treated with p-methoxymethoxy-phenylmagnesium bromide to afford an alcohol (14) in a quantative yield. The alcohol (14) was oxidized to a ketone (16), which was subjected to the Pummerer reaction and the following hydrolysis to give (+)-septorine.

引用

页码：923 / 936

页数：14

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