INTRA-OCULAR PRESSURE REDUCTION IN CHRONIC SIMPLE GLAUCOMA BY CONTINUOUS INFUSION OF DILUTE PILOCARPINE SOLUTION

Ten hospital outpatients with bilateral chronic simple glaucoma received a single drop of 2 % pilocarpine to one eye and a continuous infusion of 0-1 0% pilocarpine at a flow rate of 0-01 ml/min to the other eye (both solutions were at pH 7 2). On another occasion the treatments were -reversed. Measurements of intraocular pressure (IOP) and pupil diameter were made at 30 min intervals for 2 hours. The continuous infusion of dilute solution was as effective as the single drop of more concentrated solution in reducing IOP and in constricting the pupil; the drop was somewhat faster in producing its effect.