A PROSPECTIVE ANALYSIS OF INTRAMUSCULAR MEPERIDINE, PROMETHAZINE, AND CHLORPROMAZINE IN PEDIATRIC EMERGENCY DEPARTMENT PATIENTS

被引：46

作者：

TERNDRUP, TE

DIRE, DJ

MADDEN, CM

DAVIS, H

CANTOR, RM

GAVULA, DP

机构：

[1] Departments of Critical Care and Emergency Medicine and Pediatrics, State University, New York Health Science Center at Syracuse, Syracuse

[2] Department of Emergency Medicine, Darnall Army Community Hospital, Fort Hood, TX

来源：

ANNALS OF EMERGENCY MEDICINE | 1991年 / 20卷 / 01期

关键词：

chlorpromazine; meperidine; promethazine;

D O I：

10.1016/S0196-0644(05)81114-X

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To examine physiologic responses and efficacy of 2, 1, and 1 mg/kg IM meperidine, promethazine, and chlorpromazine (MPC), respectively, in children. Design: Prospective, unblinded trial. Setting: A university and community emergency department. Patients: Sixty-three hemodynamically and neurologically stable children. Intervention: Single dose of IM MPC. Measurements and main results: Serial respirations, heart rate, arterial systolic blood pressure, oxygen saturation, and Glasgow Coma Scale were measured at 30-minute intervals. Effectiveness was assessed by two independent observers using separate visual analog scales for cooperation and sedation. Times to sleep (27 +/- 24 minutes), sitting upright (103 +/- 87 minutes), ED discharge (4.7 +/- 2.4 hours), eating (11 +/- 7.9 hours), and normal behavior (19 +/- 15 hours) were acceptable. Minor, but statistically significant, changes in respiration rate (-1.9 +/- 0.4), heart rate (+4.5 +/- 1.8), oxygen saturation (-0.7 +/- 0.3%), and Glasgow Coma Scale (-2.5 +/- 0.6) occurred for 120 minutes after MPC. No serious complications or resuscitation were required. Mean visual analog scale scores were 5.0/10.4 or more in 71% of cases, with interobserver agreement very good (cooperation, r = .79; effectiveness, r = .80). Twenty-nine percent of children were judged insufficiently sedated. Conclusion: IM MPC is a safe and generally effective agent for ED procedures in selected children.

引用

页码：31 / 35

页数：5

共 34 条

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