IMMUNODEFICIENCY-ASSOCIATED MALIGNANT-LYMPHOMA - 3 CASES SHOWING GENOTYPIC EVIDENCE OF BOTH T-CELL AND B-CELL LINEAGES

被引:52
作者
HOLLINGSWORTH, HC [1 ]
STETLERSTEVENSON, M [1 ]
GAGNETEN, D [1 ]
KINGMA, DW [1 ]
RAFFELD, M [1 ]
JAFFE, ES [1 ]
机构
[1] NCI,PATHOL LAB,BETHESDA,MD 20892
关键词
MALIGNANT LYMPHOMA; IMMUNODEFICIENCY; IMMUNOPHENOTYPE; EPSTEIN-BARR VIRUS; GENOTYPE;
D O I
10.1097/00000478-199411000-00003
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Dual rearrangement of both immunoglobulin and T-cell receptor (TCR) genes has been described in up to 30% of precursor lymphoid neoplasms, but this phenomenon occurs rarely in lymphomas with a mature phenotype. We describe three cases of immunodeficiency-associated lymphomas, two in patients with acquired immunodeficiency syndrome (AIDS) and one in a patient with a renal transplant, in which both immunoglobulin and TCR gene rearrangements were identified. Two cases exhibited clonal J(H), clonal J(K), and clonal TCR beta gene rearrangements; the other case had clonal J(K) and TCR beta gene rearrangements with deletion of J(H). Two of these bigenotypic lesions exhibited a B-cell phenotype, and the other exhibited evidence of both a B- and T-cell phenotype, containing cytoplasmic CD3 as well as monoclonal kappa light chain. In addition, two of the cases exhibited the presence of clonal Epstein-Barr viral DNA. These observations suggest that lymphomas arising in immunodeficiency states may be more prone to disordered differentiation than those arising in an intact immune system.
引用
收藏
页码:1092 / 1101
页数:10
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