ANTICHOLINERGIC BEHAVIORAL-EFFECT OF PHENCYCLIDINE

被引：38

作者：

GLICK, SD

COX, RD

MAAYANI, S

MEIBACH, RC

机构：

[1] Department of Pharmacology, Mount Sinai School of Medicine, the City University of New York, New York, NY 10029, Fifth Avenue and

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 1-2期

关键词：

Anticholinergic; Behavior; Phencyclidine; Spatial alternation;

D O I：

10.1016/0014-2999(79)90029-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phencyclidine (PCP) impaired spatial alternation performance in rats. This effect was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by an anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism. © 1979.

引用

页码：103 / 106

页数：4

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