TREATMENT OF ADULT T-CELL LEUKEMIA BY EXTRACORPOREAL PHOTOCHEMOTHERAPY

被引:4
作者
FUTAMI, G
KIYOKAWA, T
YAMAGUCHI, K
ISHII, T
OISHI, M
JONO, M
ARAO, T
TAKATSUKI, K
机构
[1] KUMAMOTO UNIV,SCH MED,BLOOD TRANSFUS SERV,KUMAMOTO 860,JAPAN
[2] KUMAMOTO UNIV,SCH MED,DEPT DERMATOL,KUMAMOTO 860,JAPAN
[3] KUMAMOTO UNIV,COLL MED SCI,DEPT MED TECHNOL,KUMAMOTO 860,JAPAN
关键词
Adult T cell leukaemia; ATL; Extracorporeal; Leukaemia; Photochemotherapy;
D O I
10.3109/10428199009053523
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Four patients with chronic or smouldering type adult T cell leukaemia (ATL) were treated by extracorporeal photochemotherapy (photopheresis). From 4 to 8 months after starting photo-pheresis, skin lesions with ATL cell infiltration began to disappear. Cell surface markers in three patients showed improvement. In one patient, a serial decrease of soluble interleukin-2 receptor levels (950 U/ml to 620) in the serum was observed after 4 months. This pilot study suggests that photopheresis may be successfully applied in ATL. It is still necessary to continue follow-up observations in these patients and to treat a larger number of cases, before definite conclusions can be drawn in the future © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:195 / 200
页数:6
相关论文
共 17 条
[1]  
Parrish J.A., Fitzpatrick T.B., Tanenbaum L., Pathak M.A., Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light, N. Engl. J. Med, 291, pp. 1207-1211, (1974)
[2]  
Edelson R., Berger G., Gasparro F., Jegasothy B., Heald P., Wintroub B., Vonderheid E., Knobler R., Wolff K., Plewig G., McKiernan G., Christiansen I., Oster M., Honigsmann H., Wilford H., Kokoschka E., Rehle T., Perez M., Stingl G., Laroehe L., Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy, Preliminary Results, N. Engl. J. Med, 6, pp. 297-303, (1987)
[3]  
Takatsuki K., Uchiyama T., Sagawa K., Yodoi J., Adult T cell leukemia in Japan, Topics in Hematology, pp. 73-77, (1976)
[4]  
Poiesz B.J., Ruscetti F.W., Gazdar A.F., Bunn P.A., Minna J.D., Gallo R.G., Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Pro. Natl. Acad. Sci. USA, 77, pp. 7415-7419, (1980)
[5]  
Takatsuki K., Yamaguchi K., Kawano F., Nishimura H., Tsuda H., Sanada I., Gallo R.C., Essex M.E., Gross L., Adult T-cell leukemia/lympho-ma
[6]  
Clinical features and epidemiology and cytogenetic, pheno-typic and functional studies of leukemic cells, Human T-cell leukemia-lymphoma viruses, pp. 261-265, (1984)
[7]  
Yoshida M., Seiki M., Yamaguchi K., Takatsuki K., Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease, Proc. Natl Acad. Sci. USA, 81, pp. 2534-2537, (1984)
[8]  
Yamaguchi K., Seiki M., Yoshida M., Nishimura H., Kawano F., Takatsuki K., The detection of human T-cell leukemia virus proviral DNA and its application for classification and diagnosis of T-cell malignancy, Shod, 63, pp. 1235-1240, (1984)
[9]  
Yamaguchi K., Nishimura H., Kohrogi H., Jono M., Miyamoto Y., Takatsuki K., A proposal for smoldering adult T-cell leukemia
[10]  
A clinicopathologic study of five cases, Blood, 62, pp. 758-766, (1983)