ANTI-METATYPE ANTIBODY REACTIVITY - A MODEL FOR T-CELL RECEPTOR RECOGNITION

被引：10

作者：

VOSS, EW

机构：

[1] Dept of Microbiology, University of Illinois, Urbana, IL 61801, 131 Burrill Hall

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 10期

关键词：

D O I：

10.1016/0167-5699(90)90140-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-metatype (Met) antibodies are anti-immunoglobulins that specially recognize an antibody-liganded active site but lack specificity for either the ligand or the idiotype. As proposed here by Edward Voss, anti-metatype-metatype immunoglobulin interactions may serve as a model for the interactions of the T-cell receptor (TCR) with antigen-MHC (class I classII) complexes: the anti-metatype immunoglobulin reagent simulates the TCR and the liganded antibody mimics the antigen-MHC complex. Such a model addresses the dilemma of two macromolecules interacting with the sam antigenic determinant and may represent a rational approach to improve understanding of the inhibition and regulation of the immune response. © 1990.

引用

页码：355 / 357

页数：3

共 17 条

[1]

ADORINI L, 1990, IMMUNOL TODAY, V11, P21

[2]

BEDZYK WD, IN PRESS J BIOL CHEM

[3] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].