MORPHOMETRIC TRAITS AND FEMORAL HISTOMORPHOMETRY IN MICE SELECTED FOR BODY CONFORMATION

Skeleton characteristics and femoral histomorphometry were investigated in two lines of mice divergently selected for antagonistic conformations (CBi/C: high body weight-short tail; CBi/L: low body weight-long tail). An unselected control line (CBi) was used. Genotypes were a significant source of variation for almost all traits studied (body size, skeletal measurements, histomorphometry of the femur, number of caudal vertebrae) indicating that eighteen generations of artificial selection were successful in modifying phenotypes. Antagonistic selection revealed an association between the mechanisms that regulate skeleton growth and body conformation. Trunk length seemed to be dependent of the biomass a mouse would attain. Femur length and its morphometric characteristics were conditioned by other factors than body weight. The observed response in caudal vertebrae number could be explained if this character is considered as a threshold one. The selective procedure applied in this research was also useful to study other biological characters such as fat deposition, immune reactions and bone biomechanics.