ONE-POT SYNTHESIS OF ALPHA,BETA-UNSATURATED KETONES FROM TERT-BUTYLDIMETHYLSILYLDIBROMOMETHANE AND 2 DIFFERENT ALDEHYDES

被引：8

作者：

SHINOKUBO, H ^{[1
]}

OSHIMA, K ^{[1
]}

UTIMOTO, K ^{[1
]}

机构：

[1] KYOTO UNIV,FAC ENGN,DIV MAT CHEM,SAKYO KU,KYOTO 60601,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73086-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An addition of benzaldehyde to an ethereal solution of tert-butyldimethylsilyldibromo-methyllithium provided alpha-bromo-alpha-silyl ketone. Further treatment of the alpha-bromo-alpha-silyl ketone with butyllithium afforded enolate which provided beta-hydroxy-alpha-silyl ketone upon treatment with aldehyde in ether. The enolate gave alpha,beta-unsaturated ketone or monosilyl ether of 2-acyl-1,3-diol in THF instead of ether.

引用

页码：3741 / 3744

页数：4

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