THE C-32 TRIACETYL-L-RHAMNOSE DERIVATIVE OF ASCOMYCIN - A POTENT, ORALLY-ACTIVE MACROLACTONE IMMUNOSUPPRESSANT

被引：3

作者：

KOCK, K

NEWBORG, MF

HANSON, DC

COOPER, K

SHEPARD, RM

BIEHL, ML

BIGGERS, MS

RAMCHANDANI, M

SCHUTTE, G

SNYDER, JR

FERRAINA, RA

DONOVAN, C

GUADLIANA, MA

KOSTEK, GJ

COLE, SH

CONNOLLY, MJ

SAWYER, PS

TINGPO, I

BLOCKER, LW

MEISER, BM

MELVIN, LS

机构：

[1] PFIZER INC,DIV CENT RES,DEPT CANC IMMUNOL & INFECT DIS,GROTON,CT 06340

[2] PFIZER INC,DIV CENT RES,DEPT DRUG SAFETY EVALUAT,GROTON,CT 06340

[3] PFIZER INC,DIV CENT RES,DEPT DRUG METAB,GROTON,CT 06340

[4] PFIZER INC,DIV CENT RES,DEPT NAT PROD RES,GROTON,CT 06340

[5] PFIZER INC,DIV CENT RES,DEPT BIOPROC RES & DEV,GROTON,CT 06340

[6] UNIV MUNICH,DEPT CARDIAC SURG,MUNICH,GERMANY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 08期

关键词：

D O I：

10.1021/jm00008a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1255 / 1258

页数：4

共 37 条

[1]

ASAKO H, 1993, TRANSPLANTATION, V54, P686

[2]

BISHOP DK, 1992, J IMMUNOL, V148, P1049

[3]

CALNE RY, 1979, LANCETII, P1033

[4] THE AUTOIMMUNE-DISEASES [J].

CONDEMI, JJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (20) :2882-2892

[5]

DEPAULIS A, 1991, J IMMUNOL, V147, P4278

[6] THE IMMUNOSUPPRESSIVE AND TOXIC EFFECTS OF FK-506 ARE MECHANISTICALLY RELATED - PHARMACOLOGY OF A NOVEL ANTAGONIST OF FK-506 AND RAPAMYCIN [J].

DUMONT, FJ ;

STARUCH, MJ ;

KOPRAK, SL ;

SIEKIERKA, JJ ;

LIN, CS ;

HARRISON, R ;

SEWELL, T ;

KINDT, VM ;

BEATTIE, TR ;

WYVRATT, M ;

SIGAL, NH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (03) :751-760

[7] CYCLOSPORINE FOR PLAQUE-TYPE PSORIASIS - RESULTS OF A MULTIDOSE, DOUBLE-BLIND TRIAL [J].

ELLIS, CN ;

FRADIN, MS ;

MESSANA, JM ;

BROWN, MD ;

SIEGEL, MT ;

HARTLEY, AH ;

ROCHER, LL ;

WHEELER, S ;

HAMILTON, TA ;

PARISH, TG ;

ELLISMADU, M ;

DUELL, E ;

ANNESLEY, TM ;

COOPER, KD ;

VOORHEES, JJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (05) :277-284

[8]

ENLARGER BE, 1992, IMMUNOL TODAY, V13, P487

[9] RISK-FACTORS FOR CYCLOSPORINE-INDUCED NEPHROPATHY IN PATIENTS WITH AUTOIMMUNE-DISEASES [J].

FEUTREN, G ;

MIHATSCH, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (25) :1654-1660

[10]

FEUTREN G, 1990, TRANSPLANT P, V24, P55

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