CONSERVATION OF A VARIANT-SPECIFIC SURFACE-ANTIGEN GENE IN DIFFERENT TRYPANOSOME SPECIES AND SUBSPECIES

被引：21

作者：

PAYS, E ^{[1
]}

LHEUREUX, M ^{[1
]}

VERVOORT, T ^{[1
]}

STEINERT, M ^{[1
]}

机构：

[1] INST TROP GENEESKUNDE, SEROL LAB, B-2000 ANTWERP, BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1981年 / 4卷 / 5-6期

关键词：

D O I：

10.1016/0166-6851(81)90066-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Trypanosoma brucei brucei, T. b. rhodesiense, T. b. gambiense and T. evansi, the variant-specific antigen (VSA) genes are organized in families of related sequences, one of which is duplicated when expressed. Some of these VSA sequences appear to be conserved in the different species and sub-species: restriction mapping of isotypic genes of AnTat 1.8 VSA (from T. b. brucei) reveals extensive homology in T. b. rhodesiense, T. b. gambiense and T. evansi, although the genetic surrounding differs in each case. The AnTat 1.1 sequence (also from T. b. brucei) appears to be absent from T. b. gambiense DNA.

引用

页码：349 / 357

页数：9

共 23 条

[1] STRUCTURAL-ANALYSIS OF VARIANT AND INVARIANT GENES IN TRYPANOSOMES [J].

AGABIAN, N ;

THOMASHOW, L ;

MILHAUSEN, M ;

STUART, K .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1980, 29 (05) :1043-1049

[2] CROSSREACTING DETERMINANTS IN VARIANT-SPECIFIC SURFACE-ANTIGENS OF AFRICAN TRYPANOSOMES [J].

BARBET, AF ;

MCGUIRE, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (04) :1989-1993

[3] A VARIANT SURFACE GLYCOPROTEIN OF TRYPANOSOMA-BRUCEI SYNTHESIZED WITH A C-TERMINAL HYDROPHOBIC TAIL ABSENT FROM PURIFIED GLYCOPROTEIN [J].

BOOTHROYD, JC ;

CROSS, GAM ;

HOEIJMAKERS, JHJ ;

BORST, P .

NATURE, 1980, 288 (5791) :624-626

[4] THE GENES FOR VARIANT ANTIGENS IN TRYPANOSOMES [J].

BORST, P ;

FRASCH, ACC ;

BERNARDS, A ;

HOEIJMAKERS, JHJ ;

VANDERPLOEG, LHT ;

CROSS, GAM .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1980, 29 (05) :1033-1036

[5] TRYPANOSOMA-EQUIPERDUM - STUDY ON ANTIGENIC VARIATIONS IN EXPERIMENTAL TRYPANSOMIASIS OF RABBITS [J].

CAPBERN, A ;

GIROUD, C ;

BALTZ, T ;

MATTERN, P .

EXPERIMENTAL PARASITOLOGY, 1977, 42 (01) :6-13

[6] AN INTRODUCTION TO ANTIGENIC VARIATION IN TRYPANOSOMES [J].

CROSS, GAM ;

HOLDER, AA ;

ALLEN, G ;

BOOTHROYD, JC .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1980, 29 (05) :1027-1032

[7]

CROSS GAM, 1979, J GEN MICROBIOL, V113, P1

[8]

GRAY AR, 1976, BIOLOGY KINETOPLASTI, V1, P493

[9] NOVEL EXPRESSION-LINKED COPIES OF THE GENES FOR VARIANT SURFACE-ANTIGENS IN TRYPANOSOMES [J].

HOEIJMAKERS, JHJ ;

FRASCH, ACC ;

BERNARDS, A ;

BORST, P ;

CROSS, GAM .

NATURE, 1980, 284 (5751) :78-80

[10] GLYCOPEPTIDES FROM VARIANT SURFACE GLYCOPROTEINS OF TRYPANOSOMA-BRUCEI - C-TERMINAL LOCATION OF ANTIGENICALLY CROSS-REACTING CARBOHYDRATE MOIETIES [J].

HOLDER, AA ;

CROSS, GAM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1981, 2 (3-4) :135-150

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