NOREPINEPHRINE INHIBITS CALCIUM-DEPENDENT POTENTIALS IN RAT SYMPATHETIC NEURONS

被引：34

作者：

HORN, JP

MCAFEE, DA

机构：

[1] City of Hope National Medical Center, Duarte

来源：

SCIENCE | 1979年 / 204卷 / 4398期

关键词：

D O I：

10.1126/science.221979

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Norepinephrine reversibly antagonizes three calcium-dependent potentials recorded from rat postganglionic neurons. Norepinephrine inhibits the development of a shoulder on the action potential, the magnitude of the hyperpolarizing afterpotential, and the rate of rise and amplitude of the calcium spike. The action of norepinephrine is antagonized by the α-adrenergic antagonist phentolamine, but not by MJ 1999, a β-adrenergic antagonist. These results suggest that activation of an α-adrenergic receptor may antagonize a voltage-sensitive calcium current. Copyright © 1979 AAAS.

引用

页码：1233 / 1235

页数：3

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