CONTROLLED RELEASE OF 5-FLUOROURACIL FROM ADSORBENTS CONTAINING MATRICES POLYMERIZED BY RADIATION

被引：11

作者：

YOSHIDA, M

KUMAKURA, M

KAETSU, I

机构：

[1] Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, Gumma, 370-12, Takasaki

来源：

POLYMER JOURNAL | 1979年 / 11卷 / 10期

关键词：

2-Hydroxyethyl methacrylate; 5-Fluorouracil; Adsorbent; Controlled release; Glass-forming monomer; Radiation-induced polymerization; Trimethylolpropane trimethacrylate;

D O I：

10.1295/polymj.11.775

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Entrapping of 5-fluorouracil (5-FU) was carried out by radiation-induced polymerization of glass-forming monomers such as 2-hydroxyethyl methacrylate (HEMA) and trimethylolpropane trimethacrylate (TMPT) at −78°C in the presence of adsorbents. It was found that the release of 5-FU from the matrix was retarded by the addition of various adsorbents. The release rate decreased with increasing concentrations of adsorbent. The manners of release of 5-FU from the matrices containing adsorbents were studied according to Higuchi’s equation. The observation by a scanning electron microscope proved that an adsorbent was homogeneously distributed in the matrix. © 1979 The Society of Polymer Science, Japan.

引用

页码：775 / 779

页数：5

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