BRONCHODILATOR-RESISTIVE COUGH IN ATOPIC PATIENTS - BRONCHIAL REVERSIBILITY AND HYPERRESPONSIVENESS

被引：54

作者：

FUJIMURA, M

SAKAMOTO, S

MATSUDA, T

机构：

[1] Third Department of Internal Medicine, Kanazawa University, School of Medicine, Kanazawa

[2] Third Department of Internal Medicine, Kanazawa University, School of Medicine, Kanazawa 920

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 04期

关键词：

CHRONIC NONPRODUCTIVE COUGH; ATOPY; BRONCHODILATOR THERAPY; BRONCHIAL REVERSIBILITY; BRONCHIAL HYPERRESPONSIVENESS;

D O I：

10.2169/internalmedicine.31.447

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The number of atopic patients presenting only chronic non-productive cough appears to be increasing. This study was conducted to confirm the existence of non-asthmatic cough associated with atopy. We prospectively examined atopic findings, therapeutic effects of inhaled procaterol, azelastin, and/or glucocorticoids, improvement of FEV1 by bronchodilator therapy and bronchial responsiveness to methacholine in 20 patients. The cough was relieved by inhaled procaterol in 10 patients (Group 2) but not in the other 10 patients (Group 1). The increase in FEV1 by inhaled salbutamol following aminophylline injection was significantly less in Group 1 than in Group 2. Bronchial responsiveness to methacholine was normal in Group 1 while that in Group 2 was hyperreactive. These findings indicate that there is atopic non-asthmatic bronchodilator-resistive cough (Group 1) which is a different entity from bronchodilator-responsive cough (Group 2), or the so-called "cough variant asthma".

引用

页码：447 / 452

页数：6

共 22 条

[1]

McFadden E.R., Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma, N Engl J Med, 292, (1975)

[2]

Corrao W.M., Braman S.S., Irwin R.S., Chronic cough as the sole presenting manifestation of bronchial asthma, N Engl J Med, 330, (1979)

[3]

Boushey H.A., Holtzman M.J., Sheller J.R., Nadel J.A., Bronchial hyperreactivity, Am Rev Respir Des, 121, (1981)

[4]

Salem H., Aviado D.M., Antitussive drugs, Am J Med Sci, 247, (1964)

[5]

Yamaura S., Hosokawa T., Kitagawa H., Influence of tracheal muscular tone on the initiation of cough reflex, Jpn J Pharmacol, 25, (1978)

[6]

Eschenbacher W.L., Boushey H.A., Sheppard D., Alteration in osmolality of inhaled aerosols causes bronchoconstriction and cough, but absence of a permeant anion causes cough alone, Am Rev Respir Dis, 129, (1984)

[7]

Godden D.J., Barland C., Lowry R., Higenbottam T.W., Chemical specificity of coughing in man, Clin Sci, 70, (1986)

[8]

Makino S., Kobayashi S., Miyamoto T., Et al., Standard methods of provocation tests for asthma and hypersensitivity pneumonitis, Jpn J Allergol, 31, (1982)

[9]

Editorial. Cough and wheeze in asthma: are they interdependent?, Lancet, 1, (1988)

[10]

Fuller R.W., Jackson D.M., Physiology and treatment of cough, Thorax, 45, (1990)

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