REPORT OF A VARIANT T(1-15-17)(P36-Q22-Q21.1) IN A PATIENT WITH ACUTE PROMYELOCYTIC LEUKEMIA

被引：24

作者：

OSELLA, P

WYANDT, H

VOSBURGH, E

MILUNSKY, A

机构：

[1] BOSTON UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02118

[2] BOSTON UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02118

[3] BOSTON UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02118

[4] BOSTON UNIV,SCH MED,EVANS MEM DEPT CLIN RES,DEPT MED,BOSTON,MA 02118

[5] BOSTON UNIV,DEPT BIOL,BOSTON,MA 02215

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 02期

关键词：

D O I：

10.1016/0165-4608(91)90153-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome analysis of bone marrow aspirate from a 46-year-old man with acute promyelocytic leukemia (APL) revealed a variant translocation, 46,XY,t(1:15;17)(p36;q22;q21.1). The breakpoints in chromosomes 15 and 17 appear to be the same as those in the more common translocation, t(15;17), associated with APL. The common translocation has been reported in up to 80% of cases of APL. Seventeen cases with variant translocations have been reported involving 15 alone, 17 alone, or 15, 17, and some other chromosome.

引用

页码：201 / 207

页数：7

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