ENZYME ASSISTED SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES - CHIRAL BUILDING-BLOCKS FOR INOSITOL POLYPHOSPHATES

被引：46

作者：

ANDERSCH, P ^{[1
]}

SCHNEIDER, MP ^{[1
]}

机构：

[1] BERG UNIV GESAMTHSCH WUPPERTAL,FB 9,D-42097 WUPPERTAL,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)80058-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Using a short and facile synthetic protocol involving highly selective, regio- and enantioselective enzymatic esterifications as key reaction steps, readily available myo -inositol is converted into optically pure 1D-1-O-butyryl-4,6-O-dibenzoyl-myo-inositol (-) - 5, a selectively protected central intermediate for the preparation of numerous inositol phosphates.

引用

页码：2135 / 2138

页数：4

共 11 条

[1] A SYNTHESIS OF 1D-MYO-INSITOL AND 1L-MYO-INOSITOL 1,3,4,5-TETRAPHOSPHATE
BAUDIN, G
GLANZER, BI
SWAMINATHAN, KS
VASELLA, A
[J]. HELVETICA CHIMICA ACTA, 1988, 71 (05) : 1367 - 1378
[2] THE TOTAL SYNTHESIS OF MYOINOSITOL PHOSPHATES VIA MYOINOSITOL ORTHOFORMATE
BILLINGTON, DC
BAKER, R
KULAGOWSKI, JJ
MAWER, IM
VACCA, JP
DESOLMS, SJ
HUFF, JR
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (08): : 1423 - 1429
[3] RECENT DEVELOPMENTS IN THE SYNTHESIS OF MYOINOSITOL PHOSPHATES
BILLINGTON, DC
[J]. CHEMICAL SOCIETY REVIEWS, 1989, 18 (01) : 83 - 122
[4] EFFICIENT AND SYSTEMATIC SYNTHESES OF ENANTIOMERICALLY PURE AND REGIOSPECIFICALLY PROTECTED MYOINOSITOLS
BRUZIK, KS
TSAI, MD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (16) : 6361 - 6374
[5] SYNTHESIS OF (-)-SHIKIMATE AND (-)-QUINATE 3-PHOSPHATES BY DIFFERENTIATION OF THE HYDROXYL FUNCTIONS OF (-)-SHIKIMIC AND (-)-QUINIC ACIDS
CHAHOUA, L
BALTAS, M
GORRICHON, L
TISNES, P
ZEDDE, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (21) : 5798 - 5801
[6] THE SYNTHESIS OF CERAMIDE PHOSPHOINOSITOL
FRANTOVA, AY
STEPANOV, AE
BUSHNEV, AS
ZVONKOVA, EN
SHVETS, VI
[J]. TETRAHEDRON LETTERS, 1992, 33 (24) : 3539 - 3542
[7] GIGG RH, 1992, CARBOHYD RES, V234, P1
[8] AN EFFICIENT ROUTE TO D-MYO-INOSITOL 1,3,4-TRIPHOSPHATE AND D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
GOU, DM
CHEN, CS
[J]. TETRAHEDRON LETTERS, 1992, 33 (06) : 721 - 724
[9] SYNTHESIS OF MONO AND UNSYMMETRICAL BIS ORTHO-ESTERS OF SCYLLO-INOSITOL
LEE, HW
KISHI, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (22) : 4402 - 4404
[10] MERCIER D, 1968, TETRAHEDRON LETT, V31, P3459

← 1 2 →