ENZYME ASSISTED SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES - CHIRAL BUILDING-BLOCKS FOR INOSITOL POLYPHOSPHATES

被引:46
作者
ANDERSCH, P [1 ]
SCHNEIDER, MP [1 ]
机构
[1] BERG UNIV GESAMTHSCH WUPPERTAL,FB 9,D-42097 WUPPERTAL,GERMANY
关键词
D O I
10.1016/S0957-4166(00)80058-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Using a short and facile synthetic protocol involving highly selective, regio- and enantioselective enzymatic esterifications as key reaction steps, readily available myo -inositol is converted into optically pure 1D-1-O-butyryl-4,6-O-dibenzoyl-myo-inositol (-) - 5, a selectively protected central intermediate for the preparation of numerous inositol phosphates.
引用
收藏
页码:2135 / 2138
页数:4
相关论文
共 11 条
  • [1] A SYNTHESIS OF 1D-MYO-INSITOL AND 1L-MYO-INOSITOL 1,3,4,5-TETRAPHOSPHATE
    BAUDIN, G
    GLANZER, BI
    SWAMINATHAN, KS
    VASELLA, A
    [J]. HELVETICA CHIMICA ACTA, 1988, 71 (05) : 1367 - 1378
  • [2] THE TOTAL SYNTHESIS OF MYOINOSITOL PHOSPHATES VIA MYOINOSITOL ORTHOFORMATE
    BILLINGTON, DC
    BAKER, R
    KULAGOWSKI, JJ
    MAWER, IM
    VACCA, JP
    DESOLMS, SJ
    HUFF, JR
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (08): : 1423 - 1429
  • [3] RECENT DEVELOPMENTS IN THE SYNTHESIS OF MYOINOSITOL PHOSPHATES
    BILLINGTON, DC
    [J]. CHEMICAL SOCIETY REVIEWS, 1989, 18 (01) : 83 - 122
  • [4] EFFICIENT AND SYSTEMATIC SYNTHESES OF ENANTIOMERICALLY PURE AND REGIOSPECIFICALLY PROTECTED MYOINOSITOLS
    BRUZIK, KS
    TSAI, MD
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (16) : 6361 - 6374
  • [5] SYNTHESIS OF (-)-SHIKIMATE AND (-)-QUINATE 3-PHOSPHATES BY DIFFERENTIATION OF THE HYDROXYL FUNCTIONS OF (-)-SHIKIMIC AND (-)-QUINIC ACIDS
    CHAHOUA, L
    BALTAS, M
    GORRICHON, L
    TISNES, P
    ZEDDE, C
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (21) : 5798 - 5801
  • [6] THE SYNTHESIS OF CERAMIDE PHOSPHOINOSITOL
    FRANTOVA, AY
    STEPANOV, AE
    BUSHNEV, AS
    ZVONKOVA, EN
    SHVETS, VI
    [J]. TETRAHEDRON LETTERS, 1992, 33 (24) : 3539 - 3542
  • [7] GIGG RH, 1992, CARBOHYD RES, V234, P1
  • [8] AN EFFICIENT ROUTE TO D-MYO-INOSITOL 1,3,4-TRIPHOSPHATE AND D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
    GOU, DM
    CHEN, CS
    [J]. TETRAHEDRON LETTERS, 1992, 33 (06) : 721 - 724
  • [9] SYNTHESIS OF MONO AND UNSYMMETRICAL BIS ORTHO-ESTERS OF SCYLLO-INOSITOL
    LEE, HW
    KISHI, Y
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (22) : 4402 - 4404
  • [10] MERCIER D, 1968, TETRAHEDRON LETT, V31, P3459