PHOTOCHEMICAL INTERACTIONS OF METHYLENE-BLUE AND ANALOGS WITH DNA AND OTHER BIOLOGICAL SUBSTRATES

被引：305

作者：

TUITE, EM

KELLY, JM

机构：

[1] Chemistry Department, Trinity College, Dublin

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1993年 / 21卷 / 2-3期

关键词：

DNA; GUANINE; METHYLENE BLUE; PHENOTHIAZINIUM DYES; PHOTODYNAMIC DAMAGE; PHOTOOXIDATIVE DAMAGE; PHOTOSENSITIZATION; SINGLET OXYGEN; THIONINE; TYPE-I AND TYPE-II MECHANISMS;

D O I：

10.1016/1011-1344(93)80173-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The light-induced reactions of methylene blue and related phenothiazinium dyes with biological substrates are described. The properties of the excited states of the dyes, their reactions with nucleic acids and their photosensitised chemical modifications of nucleic acid bases are examined. Reports on phenothiazinium dye-induced damage to proteins, lipids, biological membranes, organelles, viruses, bacteria, mammalian cells and carcinomas are reviewed.

引用

页码：103 / 124

页数：22

共 202 条

[1] BENDING AND TWISTING DYNAMICS OF SHORT LINEAR DNAS - ANALYSIS OF THE TRIPLET ANISOTROPY DECAY OF A 209-BASE PAIR FRAGMENT BY BROWNIAN SIMULATION [J].