LIPASE-CATALYZED RESOLUTION OF ISOPROPYLIDENE GLYCEROL - EFFECT OF COSOLVENTS ON ENANTIOSELECTIVITY

被引：14

作者：

BOSETTI, A

BIANCHI, D

CESTI, P

GOLINI, P

机构：

[1] Enichem, Istituto G.Donegani, 28100, Novara, Via Fauser

来源：

BIOCATALYSIS | 1994年 / 9卷 / 1-4期

关键词：

1,3-DIOXOLANE-4-METHANOL; LIPASE PS; ENZYMATIC HYDROLYSIS;

D O I：

10.3109/10242429408992108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The resolution of 1,2-O-isopropylidene glycerol via enzyme catalyzed hydrolysis of the corresponding benzoic ester was investigated. Using lipase PS from Pseudomonas cepacia, we determined the influence of organic co-solvents on the activity and enantioselectivity of the enzyme. The performance of the lipase was correlated to the nature (logP, epsilon, mu) and the percentage of the organic media. The highest enzymatic activity was found in solvents completely miscible or completely immiscible in water. The enzyme stereoselectivity was inversely related to the logP of the solvent.

引用

页码：71 / 77

页数：7

共 12 条

[1]

ACHIWA K, 1989, CHEM PHARM BULL, V37, P1653

[2]

ARAGOZZINI F, 1991, APPL MICROBIOL BIOT, V34, P433

[3] ANHYDRIDES AS ACYLATING AGENTS IN LIPASE-CATALYZED STEREOSELECTIVE ESTERIFICATION OF RACEMIC ALCOHOLS [J].