PROSTAGLANDINS AND CONGENERS .23. SYNTHESIS OF 15-DEOXY-16-HYDROXY-16-METHYLPROSTAGLANDINS - IMPORTANCE OF THE C-13-C-14 TRANS DOUBLE-BOND FOR BRONCHODILATOR ACTIVITY

被引：7

作者：

CHEN, SML ^{[1
]}

GRUDZINSKAS, CV ^{[1
]}

机构：

[1] UCB SA,DIV PHARMACEUT,B-1060 BRUSSELS,BELGIUM

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 05期

关键词：

D O I：

10.1016/S0090-6980(79)80042-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and bronchodilator activity in the guinea pig of several 15-deoxy-16-hydroxy-16-methylprostaglandin analogs is described. The E2 (VIa) and E1 (VIb) analogs are potent bronchodilators comparable in activity to the natural prostaglandins, but possessing a longer duration of effect. Replacement of the C13-C14 trans double bond by a cis double bond or an ethylene linkage causes a substantial diminishment of this activity. © 1979.

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页码：707 / 717

页数：11

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