PHARMACOLOGY OF SACCADIC EYE-MOVEMENTS IN MAN .1. EFFECTS OF THE BENZODIAZEPINE RECEPTOR LIGANDS MIDAZOLAM AND FLUMAZENIL

被引:66
作者
BALL, DM [1 ]
GLUE, P [1 ]
WILSON, S [1 ]
NUTT, DJ [1 ]
机构
[1] SCH MED SCI BRISTOL, RECKITT & COLMAN PSYCHOPHARMACOL UNIT, UNIV WALK, BRISTOL BS8 1TD, ENGLAND
关键词
BENZODIAZEPINE RECEPTORS; FLUMAZENIL; MIDAZOLAM; SACCADIC EYE MOVEMENTS;
D O I
10.1007/BF02244431
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent slowing of peak velocity, peak acceleration, peak deceleration, reduced saccade acceleration/deceleration ratio and saccade accuracy, and increased sedation self-ratings. Changes in saccade variables and sedation ratings were significantly correlated, and also correlated with plasma midazolam concentrations. No significant changes were seen in saccade latency or anxiety self-ratings. Pharmacological specificity of these changes was demonstrated by their reversal with the benzodiazepine antagonist flumazenil. This challenge paradigm appears to be a sensitive means of assessing benzodiazepine receptor function in man.
引用
收藏
页码:361 / 367
页数:7
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