3 MEASURES FOR SIMULTANEOUSLY EVALUATING BENEFITS AND RISKS USING CATEGORICAL-DATA FROM CLINICAL-TRIALS

被引：45

作者：

CHUANGSTEIN, C

MOHBERG, NR

SINKULA, MS

机构：

[1] Research Support Biostatistics, The Upjohn Company, Kalamazoo, Michigan

[2] The Upjohn Company, Kalamazoo, Michigan

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 09期

关键词：

D O I：

10.1002/sim.4780100904

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Randomized clinical trials are typically conducted to compare the efficacy (benefits) and side effects (risks) of two or more treatments. One can use results from such trials to decide on a preferable treatment that reflects one's own evaluation of the benefits and risks. To facilitate the necessary decision making, we propose in this paper three measures for simultaneously assessing benefits and risks. All three measures use weights that reflect the relative importance of the various treatment outcomes to an individual. Two of them carry the flavour of benefit/risk ratios, while the third generalizes Hilden's measure which incorporates patients' preferences. The proposed measures and procedures are illustrated using data from a phase III clinical trial of antihypertensive compounds.

引用

页码：1349 / 1359

页数：11

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