NEUROPSYCHOPHARMACOLOGIC PROPERTIES OF A SCHUMANNIOPHYTON-PROBLEMATICUM ROOT EXTRACT

被引：6

作者：

AMADI, E ^{[1
]}

OFFIAH, NV ^{[1
]}

AKAH, PA ^{[1
]}

机构：

[1] UNIV NIGERIA,FAC PHARMACEUT SCI,DEPT PHARMACOL & TOXICOL,NSUKKA,NIGERIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 33卷 / 1-2期

关键词：

SCHUMANNIOPHYTON-PROBLEMATICUM; NEUROPSYCHOPHARMACOLOGIC; PSYCHOTIC PATIENTS;

D O I：

10.1016/0378-8741(91)90164-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Schumanniphyton problematicum is a plant popular among Nigerian native healers for the treatment of pschotic patients (madness). An extract obtained by ethanol extraction of the roots caused reductions in respiratory rate, body and limb tone, startle response and spontaneous locomotor activity after i.p. injection in mice, and was capable of inhibiting amphetamine-induced hyperactivity and stereotypic behaviour. It also induced passivity, piloerection, hypothermia and prolonged pentobarbital sleeping time. The i.p. LD50 of the extract in mice was 2.37 g/kg. The effects of the extract appear to be due to depression of central and autonomic system.

引用

页码：73 / 77

页数：5

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