SYSTEM FUNCTIONALITY AND PHYSIOCHEMICAL MODEL OF FENTANYL TRANSDERMAL SYSTEM

被引：56

作者：

GUPTA, SK

SOUTHAM, M

GALE, R

HWANG, SS

机构：

[1] ALZA Corporation, Palo Alto, CA

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 1992年 / 7卷 / 03期

关键词：

FENTANYL; PHARMACOKINETICS; TRANSDERMAL; SYSTEM FUNCTIONALITY;

D O I：

10.1016/0885-3924(92)90049-N

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Fentanyl is an opioid traditionally administered by infusion or injection and more recently in a rate-controlled transdermal dosage form. This system is a four-layer laminate on a protective liner. A backing layer seals and protects the drug reservoir, the source for continuous delivery of fentanyl. A membrane controls the release rate of fentanyl from the system. An adhesive layer attaches the system to skin and releases an initial loading dose off fentanyl. The rate of fentanyl delivery through skin is determined by the system and the skin at the application site. The release rate from the system is approximated by Fick's first law of diffusion and is controlled by the rate-controlling membrane. A complete simulation model that combines both in vitro release data and the pharmacokinetic model has been developed and used to show the influence of various physiologic and system variables on serum fentanyl concentrations.

引用

页码：S17 / S26

页数：10

共 11 条

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