THE CORRELATION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR TO ESTRADIOL, PROGESTERONE AND TESTOSTERONE LEVELS IN PERIOVULATORY FOLLICULAR-FLUID OF INVITRO FERTILIZATION PATIENTS

被引：63

作者：

BARAK, V

MORDEL, N

HOLZER, H

ZAJICEK, G

TREVES, AJ

LAUFER, N

机构：

[1] Immunology Laboratory for Tumour Diagnosis, Department of Oncology, IL-91120, Jerusalem, Kiryat Hadassah

[2] IVF Unit, Department of Obstetrics and Gynaecology, IL-91120, Jerusalem, Kiryat Hadassah

[3] Hebrew University, Hadassah Medical School, IL-91120, Jerusalem, Kiryat Hadassah

[4] H.H.Humphrey Centre for Experimental Medicine and Cancer Research, Hebrew University, Hadassah Medical Centre, IL-91120, Jerusalem, Kiryat Hadassah

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 04期

关键词：

CYTOKINES; FOLLICULAR FLUID; IL-1/IVF/TNF;

D O I：

10.1093/oxfordjournals.humrep.a137670

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Data has accumulated suggesting reciprocity between cytokines and the reproductive system. The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels. A total of 39 follicular fluid samples, from eight patients undergoing in-vitro fertilization and embryo transfer were evaluated. All of the patients were treated by a midluteal (long) protocol involving a gonadotrophin releasing hormone agonist (GnRHa) coupled with follicular phase human menopausal gonadotrophin. Mean levels in follicular fluid of IL-1, TNF, oestradiol, progesterone and testosterone were 1.58 +/- 0.42 fmol/0.1 ml, 4.69 +/- 4.18 pg/ml, 28.5 +/- 58.1 ng/ml, 2360.5 +/- 2846.3 ng/ml and 7.22 +/- 7.08 ng/ml respectively. There was a significant (P < 0.01) positive correlation between IL-1 and progesterone levels. There was no significant correlation between the different lymphokines and oestradiol secretion, oocyte fertilization, embryo quality and pregnancy rates. It is concluded that IL-1 and TNF exist in follicular fluid. It may be hypothesized that IL-1 has a local regulatory action, possibly promoting luteinization.

引用

页码：462 / 464

页数：3

共 16 条

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