HOMOLOGY MODEL-BUILDING OF THE THYROID TRANSCRIPTION FACTOR-I HOMEODOMAIN

被引:13
作者
FOGOLARI, F [1 ]
ESPOSITO, G [1 ]
VIGLINO, P [1 ]
DAMANTE, G [1 ]
PASTORE, A [1 ]
机构
[1] EUROPEAN MOLEC BIOL LAB,STRUCT & BIOCOMP PROGRAM,W-6900 HEIDELBERG,GERMANY
来源
PROTEIN ENGINEERING | 1993年 / 6卷 / 05期
关键词
HOMEODOMAIN; TRANSCRIPTION FACTOR; HOMOLOGY MODELING; 3-D STRUCTURE;
D O I
10.1093/protein/6.5.513
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.
引用
收藏
页码:513 / 519
页数:7
相关论文
共 33 条
  • [1] DETERMINATION OF THE 3-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
    BILLETER, M
    QIAN, Y
    OTTING, G
    MULLER, M
    GEHRING, WJ
    WUTHRICH, K
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (01) : 183 - 197
  • [2] THE RELATION BETWEEN THE DIVERGENCE OF SEQUENCE AND STRUCTURE IN PROTEINS
    CHOTHIA, C
    LESK, AM
    [J]. EMBO JOURNAL, 1986, 5 (04) : 823 - 826
  • [3] DIFFERENTIAL DNA-BINDING PROPERTIES OF 3 HUMAN HOMEODOMAIN PROTEINS
    CORSETTI, MT
    BRIATA, P
    SANSEVERINO, L
    DAGA, A
    AIROLDI, I
    SIMEONE, A
    PALMISANO, G
    ANGELINI, C
    BONCINELLI, E
    CORTE, G
    [J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (17) : 4465 - 4472
  • [4] SEVERAL REGIONS OF ANTENNAPEDIA AND THYROID TRANSCRIPTION FACTOR-I HOMEODOMAINS CONTRIBUTE TO DNA-BINDING SPECIFICITY
    DAMANTE, G
    DILAURO, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) : 5388 - 5392
  • [5] DAYRINGER HE, 1986, J MOL GRAPHICS, V4, P82
  • [6] ANTP-TYPE HOMEODOMAINS HAVE DISTINCT DNA-BINDING SPECIFICITIES THAT CORRELATE WITH THEIR DIFFERENT REGULATORY FUNCTIONS IN EMBRYOS
    DESSAIN, S
    GROSS, CT
    KUZIORA, MA
    MCGINNIS, W
    [J]. EMBO JOURNAL, 1992, 11 (03) : 991 - 1002
  • [7] DIFFERENTIAL DNA-SEQUENCE RECOGNITION IS A DETERMINANT OF SPECIFICITY IN HOMEOTIC GENE-ACTION
    EKKER, SC
    VONKESSLER, DP
    BEACHY, PA
    [J]. EMBO JOURNAL, 1992, 11 (11) : 4059 - 4072
  • [8] POLYELECTROLYTES IN MIXED SALTS - SCATCHARD PLOTS OBTAINED BY MEANS OF POISSON-BOLTZMANN CALCULATIONS
    FOGOLARI, F
    MANZINI, G
    QUADRIFOGLIO, F
    [J]. BIOPHYSICAL CHEMISTRY, 1992, 43 (02) : 213 - 219
  • [9] HOMEO BOXES IN THE STUDY OF DEVELOPMENT
    GEHRING, WJ
    [J]. SCIENCE, 1987, 236 (4806) : 1245 - 1252
  • [10] THYROID NUCLEAR FACTOR-I (TTF-1) CONTAINS A HOMEODOMAIN AND DISPLAYS A NOVEL DNA-BINDING SPECIFICITY
    GUAZZI, S
    PRICE, M
    DEFELICE, M
    DAMANTE, G
    MATTEI, MG
    DILAURO, R
    [J]. EMBO JOURNAL, 1990, 9 (11) : 3631 - 3639