INHIBITION OF LIPID-PEROXIDATION BY A NEW FAMILY OF IRON CHELATORS - COMPARISON WITH DESFERRIOXAMINE

被引：8

作者：

RACHIDI, S

COUDRAY, C

BARET, P

GELON, G

PIERRE, JL

FAVIER, A

机构：

[1] CHR UNIV GRENOBLE, BIOCHIM LAB C, F-38043 GRENOBLE, FRANCE

[2] UNIV GRENOBLE 1, LEDSS, CHIM BIOMIMET LAB, CNRS, URA D0332, F-38041 GRENOBLE, FRANCE

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1994年 / 41卷 / 1-2期

关键词：

IRON; SIDEROPHORES; DESFERRIOXAMINE; HYDROXYL RADICAL; LIPID PEROXIDATION;

D O I：

10.1007/BF02917219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catechol derived siderophores are the most powerful currently known iron chelators. We have intended tripodal ligands built with o,o' dihydroxy biaryl subunits (A, B, and C). We described antioxidant properties of this new family of iron chelators. Superoxide-dependent hydroxyl radical system was used. Peroxidation of different lipid-containing systems (liposomes, erythrocyte membrane ghosts, tissue homogenates) were also investigated. The antioxidant properties of these new chelators have been related to that of desferrioxamine as a reference compound. In general manner, the results depended mainly on the model used in the assay. However, C presents an antioxidant effect close to that of desferrioxamine.

引用

页码：77 / 87

页数：11

共 29 条

[1] TRIPODAL LIGANDS POSSESSING 6 CONVERGENT HYDROXYL-GROUPS A NOVEL FAMILY OF IRON SEQUESTERING AGENTS BASED ON O,O'-DIHYDROXYBIPHENYL SUBUNITS [J].