IDENTIFICATION OF A NEW MEMBER OF THE PROTEGRIN FAMILY BY CDNA CLONING

被引：89

作者：

ZHAO, CQ ^{[1
]}

LIU, LD ^{[1
]}

LEHRER, RI ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, CTR HLTH SCI, DEPT MED, LOS ANGELES, CA 90024 USA

来源：

FEBS LETTERS | 1994年 / 346卷 / 2-3期

关键词：

PROTEGRIN; CDNA CLONING; PG-4; CATHELIN; ANTIMICROBIAL PEPTIDE;

D O I：

10.1016/0014-5793(94)00493-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The porcine leukocyte protegrins are a family of cysteine-rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG-4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5' and (in some instances) 3' sequences present in structurally dissimilar antimicrobial and LPS-binding peptides of animal leukocytes.

引用

页码：285 / 288

页数：4

共 19 条

[1] AMINO-ACID-SEQUENCE OF PR-39 - ISOLATION FROM PIG INTESTINE OF A NEW MEMBER OF THE FAMILY OF PROLINE-ARGININE-RICH ANTIBACTERIAL PEPTIDES
AGERBERTH, B
LEE, JY
BERGMAN, T
CARLQUIST, M
BOMAN, HG
MUTT, V
JORNVALL, H
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 202 (03): : 849 - 854
[2] MECHANISM OF C-TERMINAL AMIDE FORMATION BY PITUITARY ENZYMES
BRADBURY, AF
FINNIE, MDA
SMYTH, DG
[J]. NATURE, 1982, 298 (5875) : 686 - 688
[3] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[4] PURIFICATION, COMPOSITION, AND ACTIVITY OF 2 BACTENECINS, ANTIBACTERIAL PEPTIDES OF BOVINE NEUTROPHILS
GENNARO, R
SKERLAVAJ, B
ROMEO, D
[J]. INFECTION AND IMMUNITY, 1989, 57 (10) : 3142 - 3146
[5] PROTEGRINS - LEUKOCYTE ANTIMICROBIAL PEPTIDES THAT COMBINE FEATURES OF CORTICOSTATIC DEFENSINS AND TACHYPLESINS
KOKRYAKOV, VN
HARWIG, SSL
PANYUTICH, EA
SHEVCHENKO, AA
ALESHINA, GM
SHAMOVA, OV
KORNEVA, HA
LEHRER, RI
[J]. FEBS LETTERS, 1993, 327 (02) : 231 - 236
[6] COMPLEMENTARY-DNA SEQUENCE OF RABBIT CAP18 - A UNIQUE LIPOPOLYSACCHARIDE BINDING-PROTEIN
LARRICK, JW
MORGAN, JG
PALINGS, I
HIRATA, M
YEN, MH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 179 (01) : 170 - 175
[7] PIG LEUKOCYTE CYSTEINE PROTEINASE-INHIBITOR (PLCPI), A NEW MEMBER OF THE STEFIN FAMILY
LENARCIC, B
RITONJA, A
DOLENC, I
STOKA, V
BERBIC, S
PUNGERCAR, J
STRUKELJ, B
TURK, V
[J]. FEBS LETTERS, 1993, 336 (02) : 289 - 292
[8] LEVY O, 1993, J BIOL CHEM, V268, P6058
[9] O-18 ISOTOPIC C-13 NMR SHIFT AS PROOF THAT BIFUNCTIONAL PEPTIDYLGLYCINE ALPHA-AMIDATING ENZYME IS A MONOOXYGENASE
MERKLER, DJ
KULATHILA, R
CONSALVO, AP
YOUNG, SD
ASH, DE
[J]. BIOCHEMISTRY, 1992, 31 (32) : 7282 - 7288
[10] PRIMARY STRUCTURE OF 3 CATIONIC PEPTIDES FROM PORCINE NEUTROPHILS - SEQUENCE DETERMINATION BY THE COMBINED USAGE OF ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY AND EDMAN DEGRADATION
MIRGORODSKAYA, OA
SHEVCHENKO, AA
ABDALLA, KOMA
CHERNUSHEVICH, IV
EGOROV, TA
MUSOLIAMOV, AX
KOKRYAKOV, VN
SHAMOVA, OV
[J]. FEBS LETTERS, 1993, 330 (03) : 339 - 342

← 1 2 →