TISSUE DISTRIBUTION OF LIPOSOMES PREPARED FROM SYNTHETIC AMPHIPHILES AFTER INTRAPERITONEAL INJECTION INTO MICE

被引：2

作者：

GOTO, R

IBUKI, YD

机构：

[1] Laboratory of Radiation Chemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka-ken, 422, 52-1, Yada

来源：

APPLIED RADIATION AND ISOTOPES | 1994年 / 45卷 / 01期

关键词：

D O I：

10.1016/0969-8043(94)90148-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The tissue distribution of Tc-99m-labeled vesicles prepared from synthetic amphiphiles containing an amino acid residue (synthetic liposomes) after intraperitoneal (i.p.) injection in Ehrlich solid tumor-bearing mice was investigated. Synthetic liposomes were labeled with Tc-99m using stearylamine-diethylenetriaminepentaacetic acid as a chelator. The accumulation of the synthetic liposomes in liver decreased and that in pancreas significantly increased in comparison with those after intravenous injection. Gamma camera images after i.p. injection also indicated high uptake of the synthetic liposomes in pancreas. The radioactivity of the synthetic liposomes in vitro was taken up most highly in pancreas among some excised organs.

引用

页码：57 / 62

页数：6

共 19 条

[1]

ABRA RM, 1980, RES COMMUN CHEM PATH, V29, P349

[2] LIPOSOMES WITH PROLONGED CIRCULATION TIMES - FACTORS AFFECTING UPTAKE BY RETICULOENDOTHELIAL AND OTHER TISSUES [J].

ALLEN, TM ;

HANSEN, C ;

RUTLEDGE, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 981 (01) :27-35

[3] LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].

ALLEN, TM ;

HANSEN, C ;

MARTIN, F ;

REDEMANN, C ;

YAUYOUNG, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1066 (01) :29-36

[4] LARGE UNILAMELLAR LIPOSOMES WITH LOW UPTAKE INTO THE RETICULOENDOTHELIAL SYSTEM [J].

ALLEN, TM ;

CHONN, A .

FEBS LETTERS, 1987, 223 (01) :42-46

[5] LIPOSOMES FOR THE SUSTAINED DRUG RELEASE INVIVO [J].

BLUME, G ;

CEVC, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1029 (01) :91-97

[6] EFFECTS OF ALKYL GLYCOSIDES INCORPORATED INTO LIPOSOMES PREPARED FROM SYNTHETIC AMPHIPHILES ON THEIR TISSUE DISTRIBUTION IN EHRLICH SOLID TUMOR-BEARING MICE [J].

DAICHO, Y ;

OKADA, S ;

GOTO, R .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1107 (01) :61-69

[7] INVIVO FATE OF LARGE UNILAMELLAR SPHINGOMYELIN-CHOLESTEROL LIPOSOMES AFTER INTRAPERITONEAL AND INTRAVENOUS-INJECTION INTO RATS [J].

ELLENS, H ;

MORSELT, H ;

SCHERPHOF, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 674 (01) :10-18

[8] LIPOSOME FORMULATIONS WITH PROLONGED CIRCULATION TIME IN BLOOD AND ENHANCED UPTAKE BY TUMORS [J].

GABIZON, A ;

PAPAHADJOPOULOS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6949-6953

[9] LIPOSOMES PREPARED FROM SYNTHETIC AMPHIPHILES .2. THEIR INTERACTION WITH EHRLICH ASCITES TUMOR-CELLS AND TISSUE DISTRIBUTION IN EHRLICH SOLID TUMOR-BEARING MICE [J].

GOTO, R ;

KUBO, H ;

DAICHO, Y ;

OKADA, S .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (10) :2805-2809

[10]

GOTO R, 1989, CHEM PHARM BULL, V37, P1351

← 1 2 →