A MILD AND EFFICIENT ROUTE TO THE PHARMACOPHORE OF THE ENEDIYNE ANTITUMOR AGENTS - (Z)-1,6-[BIS (TRIMETHYLSILYL)]-HEX-3-ENE-1,5-DIYNE VIA A NOVEL CARBENOID COUPLING REACTION

被引：29

作者：

HUBER, RS ^{[1
]}

JONES, GB ^{[1
]}

机构：

[1] CLEMSON UNIV,DEPT CHEM,CLEMSON,SC 29634

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)76998-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Z)-1,6-[Bis (trimethylsilyl)] -hex-3-ene-1,5-diyne has been prepared in high yield and in one pot from trimethylsilylpropargyl bromide by a remarkably stereoselective tandem carbenoid coupling-HX elimination sequence.

引用

页码：2655 / 2658

页数：4

共 7 条

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