DISORAZOL-A, AN EFFICIENT INHIBITOR OF EUKARYOTIC ORGANISMS ISOLATED FROM MYXOBACTERIA

被引：57

作者：

IRSCHIK, H ^{[1
]}

JANSEN, R ^{[1
]}

GERTH, K ^{[1
]}

HOFLE, G ^{[1
]}

REICHENBACH, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,DEPT CHEM NAT PROD,W-3300 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 01期

关键词：

D O I：

10.7164/antibiotics.48.31

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic, disorazol, was isolated from the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 12. It is a macrocyclic compound containing two oxazole rings. The antibiotic acted against many fungi and mammalian cell cultures. The latter responded to extremely low doses (MIC 3 similar to 30 pg/ml). None of the tested bacteria and yeasts were inhibited.

引用

页码：31 / 35

页数：5

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