NITROHETEROCYCLIC ANTIMICROBIAL AGENTS .I. NITROTHIAZOLECARBOXALDEHYDE DERIVATIVES

A series of derivatives of 2-thiazolecarboxaldehyde, 2-nitro-5-thiazolecarboxaldehyde, 5-nitro-2-thiazolecarboxaldehyde, and 4-nitro-2-thiazolecarboxaldehyde was synthesized and assayed for antimicrobial activity. Only 2,5-disubstituted thiazoles in which one substituent is a nitro group were active against microorganisms in vitro. 1-{[(5-Nitro-2-thiazolyl)methylene]amino}-2-imidazolidinone exhibited activity against Staphylococcus aureus and Escherichia coli infections in mice. © 1969, American Chemical Society. All rights reserved.