ENANTIOSELECTIVE TOTAL SYNTHESIS OF NATURAL (+)-LUCIDULINE

被引：94

作者：

OPPOLZER, W

PETRZILKA, M

机构：

[1] Département de Chimie Organique, Université de Genève, Genève

来源：

HELVETICA CHIMICA ACTA | 1978年 / 61卷 / 08期

关键词：

D O I：

10.1002/hlca.19780610802

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The naturally occurring Lycopodium alkaloid (+)‐luciduline (1) has been synthesized from (R)‐5‐methyl‐cyclohex‐2‐en‐1‐one (12) by a sequence of seven steps (s. Scheme 6) in 33% overall yield. The key step 4→6 presumably involves a transient nitrone 5 which undergoes a highly regioselective intramolecular addition to a non‐polarized olefinic bond. Copyright © 1978 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：2755 / 2762

页数：8

共 25 条

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