DIAGNOSTIC-VALUE OF T-CELL RECEPTOR BETA GENE REARRANGEMENT ANALYSIS ON PERIPHERAL-BLOOD LYMPHOCYTES OF PATIENTS WITH ERYTHRODERMA

被引:43
作者
BAKELS, V
VANOOSTVEEN, JW
GORDIJN, RLJ
WALBOOMERS, JMM
MEIJER, CJLM
WILLEMZE, R
机构
[1] FREE UNIV AMSTERDAM HOSP,DEPT DERMATOL,DE BOELELAAN 1117,1081 HV AMSTERDAM,NETHERLANDS
[2] FREE UNIV AMSTERDAM HOSP,DEPT PATHOL,1081 HV AMSTERDAM,NETHERLANDS
关键词
D O I
10.1111/1523-1747.ep12486767
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Differentiation between Sezary's syndrome (SS) and benign forms of erythroderma may be extremely difficult. In this study T-cell receptor beta (TCR-beta) gene rearrangement analysis was performed on peripheral blood lymphocytes (PBL) from 32 patients with erythroderma, including 10 patients with SS, three patients with another type of cutaneous T-cell lymphoma, and 19 patients with a benign form of erythroderma. The aim of this study was to define the sensitivity and specificity of this technique in the diagnosis of SS. Clonal TCR-beta gene rearrangements were found in eight of 10 patients with SS, one T-CLL patient, one of two patients with erythrodermic mycosis fungoides, and only one of 19 patients from the benign group. In the two "false-negative" cases of SS clonal TCR-beta gene rearrangements were detected in PBL obtained during follow-up. The results indicate that TCR-beta gene rearrangement analysis on PBL is a sensitive and highly specific technique, that may contribute significantly to the differential diagnosis of patients with erythroderma. However, because both "false-positive" and "false-negative" results may occur, the results of gene-rearrangement analysis should always be considered in conjunction with clinical, histologic, and immunophenotypical data.
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页码:782 / 786
页数:5
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