CORTICOSTEROID DETERMINATION IN SKIN PREPARATIONS BY A REACTION-RATE METHOD

被引：6

作者：

KOUPPARIS, MA

WALCZAK, KM

MALMSTADT, HV

机构：

[1] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801

[2] UNIV ATHENS,ANALYT CHEM LAB,ATHENS,GREECE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

Betamethasone valerate—analysis; skin preparations; reaction rate method; Betamethasone—analysis; Corticosteroids—analysis; Fluocinolone acetonide—analysis; Skin preparations—analysis; corticosteroids; Triamcinolone acetonide—analysis;

D O I：

10.1002/jps.2600681204

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A reaction rate method for the determination of betamethasone, betamethasone valerate, triamcinolone acetonide, and fluocinolone acetonide is described. The method is based on a modification of the widely accepted blue tetrazolium reaction. Analysis times of 30–70 sec are required. Relative standard deviations of 0.3–1.9% are obtained, and the analytical working curves are linear. Analysis of pharmaceutical skin preparations by the new method gave results that correlated well with the time‐consuming standard equilibrium method. Analysis of betamethasone and betamethasone valerate mixtures by measuring absorbance values at two different times was performed also. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1479 / 1482

页数：4

共 20 条

[1] STABILIZATION OF TETRAZOLIUM BLUE ASSAY FOR TRIAMCINOLONE [J].