DESIGN OF SPECIFIC IMMUNOGENS USING FILAMENTOUS PHAGE AS THE CARRIER

被引：51

作者：

MINENKOVA, OO ^{[1
]}

ILYICHEV, AA ^{[1
]}

KISHCHENKO, GP ^{[1
]}

PETRENKO, VA ^{[1
]}

机构：

[1] NPO VEKTOR, RES & TECHNOL INST BIOL ACT SUBST, BERDSK 633190, RUSSIA

来源：

GENE | 1993年 / 128卷 / 01期

关键词：

PHAGE DISPLAY; PROTEIN FUSION; MAJOR COAT PROTEIN; HIV; GAG PROTEIN;

D O I：

10.1016/0378-1119(93)90157-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Earlier, we developed an expression vector allowing exposure of short peptides on the surface of bacteriophage M 1 3. It was used to obtain a recombinant phage carrying an antigenic determinant of HIV 1 p 17 Gag protein. Immunoglobulin elicited by immunizing rabbits with the phage reacted with the 17-kDa core protein of the virus and with its polyprotein precursor, p55, on Western blots of HIV1 viral proteins. The results of present experiments may be useful in vaccine development.

引用

页码：85 / 88

页数：4

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