Intermediate filament structure and assembly

被引:137
作者
Stewart, Murray [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
D O I
10.1016/S0955-0674(05)80002-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Intermediate filaments are constructed from two-chain a-helical coiled-coil molecules arranged on an imperfect helical lattice. Filament structure and assembly can be influenced at several different structural levels, including molecular structure, oligomer formation and filament nucleation and elongation. Consequently, it can sometimes be difficult to interpret mutagensis data unequivocally, although regions near the amino and carboxyl termini of the rod domain of the molecule are known to be important for the production of native filaments. Imperfections in molecular packing may be important in filament assembly and dynamics.
引用
收藏
页码:3 / 11
页数:9
相关论文
共 62 条
[1]   THE NUCLEAR LAMINA IS A MESHWORK OF INTERMEDIATE-TYPE FILAMENTS [J].
AEBI, U ;
COHN, J ;
BUHLE, L ;
GERACE, L .
NATURE, 1986, 323 (6088) :560-564
[2]   THE MOLECULAR-BIOLOGY OF INTERMEDIATE FILAMENT PROTEINS [J].
ALBERS, K ;
FUCHS, E .
INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1992, 134 :243-+
[3]  
ALMAHBOBI G, 1992, J CELL SCI, V101, P383
[4]  
[Anonymous], 1975, THERMODYNAMICS POLYM
[5]   MOLECULAR-INTERACTIONS IN MYOSIN ASSEMBLY - ROLE OF THE 28-RESIDUE CHARGE REPEAT IN THE ROD [J].
ATKINSON, SJ ;
STEWART, M .
JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (01) :7-13
[6]   INTERMEDIATE FILAMENTS FORMED DENOVO FROM TAIL-LESS CYTOKERATINS IN THE CYTOPLASM AND IN THE NUCLEUS [J].
BADER, BL ;
MAGIN, TM ;
FREUDENMANN, M ;
STUMPP, S ;
FRANKE, WW .
JOURNAL OF CELL BIOLOGY, 1991, 115 (05) :1293-1307
[7]  
BRIDGER JM, 1993, J CELL SCI IN PRESS
[8]  
BROWN KD, 1992, J CELL SCI, V102, P19
[9]   THE GENETIC-BASIS OF EPIDERMOLYTIC HYPERKERATOSIS - A DISORDER OF DIFFERENTIATION-SPECIFIC EPIDERMAL KERATIN GENES [J].
CHENG, J ;
SYDER, AJ ;
YU, QC ;
LETAI, A ;
PALLER, AS ;
FUCHS, E .
CELL, 1992, 70 (05) :811-819
[10]  
CHIN SSM, 1991, J CELL SCI, V99, P335