NEW 1,2,6-THIADIAZINE DIOXIDE ACYCLONUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION

被引：14

作者：

ESTEBAN, AI

JUANES, O

CONDE, S

GOYA, P

DECLERCQ, E

MARTINEZ, A

机构：

[1] CSIC, INST QUIM MED, E-28006 MADRID, SPAIN

[2] KATHOLIEKE UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 11期

关键词：

D O I：

10.1016/0968-0896(95)00140-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.

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页码：1527 / 1535

页数：9

相关论文

共 19 条

[1] REACTIVITY OF MALONONITRILE TOWARDS SULFAMIDE AND N-SUBSTITUTED SULFAMIDES - SYNTHESIS AND HYDROLYSIS REACTIONS OF 3,5-DIAMINO-1,2,6-THIADIAZINE 1,1-DIOXIDES [J].

ALKORTA, I ;

ARAN, VJ ;

BIELSA, AG ;

STUD, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (05) :1271-1275

[2] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].

BAX, A ;

SUBRAMANIAN, S .

JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) :565-569

[3] STRUCTURE ELUCIDATION OF THE ANTIBIOTIC DESERTOMYCIN THROUGH THE USE OF NEW TWO-DIMENSIONAL NMR TECHNIQUES [J].

BAX, A ;

ASZALOS, A ;

DINYA, Z ;

SUDO, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (25) :8056-8063

[4] EFFECT OF ACYCLIC PYRIMIDINES RELATED TO 9-[(1,3-DIHYDROXY-2-PROPOXY)METHYL]GUANINE ON HERPESVIRUSES [J].

BEAUCHAMP, LM ;

SERLING, BL ;

KELSEY, JE ;

BIRON, KK ;

COLLINS, P ;

SELWAY, J ;

LIN, JC ;

SCHAEFFER, HJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) :144-149

[5] SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME ACYCLIC AND C-ACYCLIC PYRROLO[2,3-D]PYRIMIDINE NUCLEOSIDE ANALOGS [J].

BENNETT, SM ;

NGUYENBA, N ;

OGILVIE, KK .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (08) :2162-2173

[6]

Chu C. K., 1993, NUCLEOSIDES NUCLEOTI

[7] CHEMISTRY AND ANTIVIRAL ACTIVITIES OF ACYCLONUCLEOSIDES [J].

CHU, CK ;

CUTLER, SJ .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (02) :289-319

[8]

DECLERCQ E, 1994, MIN EUR S, P108

[9] LIPASE-MEDIATED ACYLATION OF ACYCLONUCLEOSIDES - APPLICATION TO NOVEL FLUOROQUINOLONE DERIVATIVES [J].

DELACRUZ, A ;

ELGUERO, J ;

GOTOR, V ;

GOYA, P ;

MARTINEZ, A ;

MORIS, F .

SYNTHETIC COMMUNICATIONS, 1991, 21 (14) :1477-1480

[10]

DELACRUZ A, 1992, J CHEM RES, P216