MORPHINE SELF-ADMINISTRATION AND EEG POWER SPECTRA IN RAT

被引：12

作者：

YOUNG, GA ^{[1
]}

STEINFELS, GF ^{[1
]}

KHAZAN, N ^{[1
]}

GLASER, EM ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21201

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1978年 / 9卷 / 04期

关键词：

EEG; Morphine self-administration; Power spectra;

D O I：

10.1016/0091-3057(78)90053-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Power spectral analyses were used to study changes in cortical EEG during morphine self-administration in freely-moving dependent rats prepared with chronic cortical and muscle electrodes and with permanent indwelling IV cannulae. As time progressed from a morphine self-injection toward another injection, a significant spectral shift of the EEG to lower frequencies occurred during successive REM sleep episodes. Each morphine self-injection reinstated the predominance of higher frequencies in the EEG spectra. These EEG changes which preceded lever pressing may reflect changes in morphine plasma levels and in the state of the CNS that precede drug-seeking behavior. © 1978.

引用

页码：525 / 527

页数：3

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