SANGUINARINE LEVELS IN BIOLOGICAL SAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：9

作者：

REINHART, P ^{[1
]}

HARKRADER, R ^{[1
]}

WYLIE, R ^{[1
]}

YEWEY, G ^{[1
]}

VANHORNE, KC ^{[1
]}

机构：

[1] JONES CHROMATOG,LAKEWOOD,CO 80227

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80549-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

A high-performance liquid chromatographic method is presented for the analysis of the benzophenanthridine alkaloid, sanguinarine, found in plant extracts. The method is demonstrated to be applicable to analyzing samples such as saliva and gingival crevicular fluid for sanguinarine following a simple acidified methanolic extraction step. The method utilizes an ethyl silane column with acidic and basic ion-pairing reagents in the mobile phase with a limit of detection of 3 ng of sanguinarine in a sample.

引用

页码：425 / 434

页数：10

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