EFFECTS OF GENETIC, EPIGENETIC, AND ENVIRONMENTAL-FACTORS ON TAXOL CONTENT IN TAXUS-BREVIFOLIA AND RELATED SPECIES

被引:135
作者
WHEELER, NC
JECH, K
MASTERS, S
BROBST, SW
ALVARADO, AB
HOOVER, AJ
SNADER, KM
机构
[1] NCI,FREDERICK CANC RES & DEV CTR,DYNCORP,PROGRAM RESOURCES INC,FREDERICK,MD 21702
[2] NCI,DCT,DTP,NAT PROD BRANCH,FREDERICK,MD 21702
来源
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 04期
关键词
D O I
10.1021/np50082a005
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The demand for taxol, a promising cancer chemotherapeutic agent, far exceeds supply. Presently, taxol is derived from the bark of the Pacific yew, Taxus brevifolia, a small, slow-growing evergreen tree native to the northwestern United States. Knowledge of the distribution and magnitude of genetic and non-genetic sources of variation in taxol content in the genus Taxus is necessary if supply issues are to be met through plant harvesting. Analytical determinations of taxol, cephalomannine, and baccatin III in more than 200 trees representing several populations of T. brevifolia and other yew taxa indicate that (1) significant variation in taxane content exists among and within populations and species, (2) taxol levels exceeding those reported for T. brevifolia bark were found in shoots of individual trees from most taxa studied, and (3) the season in which samples are collected and handling procedures can influence taxane content.
引用
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页码:432 / 440
页数:9
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