RISKS OF IMMUNODEFICIENCY, AIDS, AND DEATH RELATED TO PURITY OF FACTOR-VIII CONCENTRATE

被引：45

作者：

GOEDERT, JJ

COHEN, AR

KESSLER, CM

EICHINGER, S

SEREMETIS, SV

RABKIN, CS

YELLIN, FJ

ROSENBERG, PS

ALEDORT, LM

机构：

[1] NCI,VIRAL EPIDEMIOL BRANCH,AIDS & CANC SECT,ROCKVILLE,MD

[2] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

[3] GEORGE WASHINGTON UNIV HOSP,WASHINGTON,DC

[4] UNIV VIENNA,VIENNA,AUSTRIA

[5] MT SINAI MED CTR,NEW YORK,NY 10029

[6] COMP SCI CORP,PROFESS SERV GRP,ROCKVILLE,MD

[7] NCI,EPIDEMIOL METHODS SECT,ROCKVILLE,MD

来源：

LANCET | 1994年 / 344卷 / 8925期

关键词：

D O I：

10.1016/S0140-6736(94)92345-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In HIV-infected subjects with haemophilia, CD4 counts seem to fall more slowly in those on high-purity factor VIII (FVIII) than on intermediate-purity product. We evaluated whether risks for AIDS or death were associated with either product among 411 HIV-infected individuals. The relative hazard of AIDS was slightly elevated for both current (1.34 per month) and cumulative (1.01 per month) use of high-purity products (neither significant). The corresponding hazards for death were 1.49 and 1.03 (neither significant). Thus we found no evidence that high-purity FVIII concentrates retard the development of AIDS.

引用

页码：791 / 792

页数：2

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