SODIUM BENZYLIDENEASCORBATE INDUCES APOPTOSIS IN HIV-REPLICATING U1 CELLS

被引:7
作者
AOKI, K
NAKASHIMA, H
HATTORI, T
SHIOKAWA, D
NIIMI, E
TANIMOTO, Y
MARUTA, H
UCHIUMI, F
KOCHI, M
YAMAMOTO, N
TANUMA, S
机构
[1] SCI UNIV TOKYO,FAC PHARMACEUT SCI,DEPT BIOCHEM,SHINJUKU KU,TOKYO 162,JAPAN
[2] TOKYO MED & DENT UNIV,SCH MED,DEPT MICROBIOL,TOKYO 113,JAPAN
[3] UNIV TOKYO,FAC SCI,DEPT BIOPHYS & BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN
[4] SCI UNIV TOKYO,BIOSCI RES INST,NODA,CHIBA 278,JAPAN
[5] ICHIJOUKAI HOSP,ICHIKAWA,CHIBA,JAPAN
关键词
HIV REPLICATION; APOPTOSIS; BENZYLIDENEASCORBATE; ANTI-HIV DRUG;
D O I
10.1016/0014-5793(94)00832-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
U1 cells, a subclone of U937 cells chronically infected with human immunodeficiency virus type 1 (HIV-1), produced HIV-1 only in the presence of inducers such as 12-O-tetradecanoxylphorbol 13-acetate (TPA) or tumor necrosis factor (TNF)-alpha. The expression of HIV-antigen on U1 cells induced by TPA or TNF-alpha was found to be prevented by sodium 5,6-benzylidene-L-ascorbate (SBA) in a concentration-dependent manner. Treatment of U1 cells with SBA in the presence of inducers resulted in cell death with cell shrinkage, chromatin condensation and DNA fragmentation into nucleosomal oligomers, characteristics of apoptosis. In contrast, SBA had scarcely any apoptotic effect on U1 cells in the absence of inducers. SBA did not also induce apoptosis in parental U937 cells in the presence or absence of inducers. These results suggest that HIV-replicating U1 cells selectively undergo apoptosis on treatment with SBA.
引用
收藏
页码:105 / 108
页数:4
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