TRANSCRIPTIONAL ACTIVATION OF THE IL-6 RESPONSE ELEMENT IN THE JUNB PROMOTER IS MEDIATED BY MULTIPLE STAT FAMILY PROTEINS

被引：58

作者：

FUJITANI, Y ^{[1
]}

NAKAJIMA, K ^{[1
]}

KOJIMA, H ^{[1
]}

NAKAE, K ^{[1
]}

TAKEDA, T ^{[1
]}

HIRANO, T ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, BIOMED RES CTR, DIV MOLEC ONCOL, SUITA, OSAKA 565, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-6 signals activate an IL-6 response element in the junB promoter, JRE-IL6, in a Ras-independent manner. IL-6 rapidly induced a DNA-binding activity to the Ets binding site of JRE-IL6 (JEBS), one of necessary DNA motifs of the IL-6 response element. The IL-6-induced JEBS-binding activity was indistinguishable from those to acute phase response element (APRE) in both kinetics of induction and its DNA-binding specificity. Purified APRE binding factors (APRFs) from IL-6-stimulated rat liver were found to be composed of multiple Stat3-related proteins and Stat1. Moreover the purified APRFs specifically made a complex with JRE-IL6 with the same mobility as that observed in the crude extracts. These results indicate that an immediate early signal of IL-6 leading to activation of JRE-IL6 is mediated by STAT family transcription factors. (C) 1994 Academic Press, Inc.

引用

页码：1181 / 1187

页数：7

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